Objective This article provides a reference for choosing a reasonable, reliable animal species,modeling method and evaluation index system, and provides a reliable animal model combining disease and syndrome for Chinese medicine syndrome differentiation. Methods We systematically searched the last 30 years for literature on animal models that combine a disease and a syndrome for six diseases related to diabetes mellitus, obesity, hyperlipoidemia, hypertension, hyperuricemia, and gout. Then we collected and organized the relevant literature, and summarized animalrelated parameters, modeling method, evidence types and evaluation systems. Results Among the 243 literatures retrieved, 132 literatures involved diabetes. The syndromes include deficiency of both qi and yin,damp heat trapped spleen type, internal heat due to yin deficiency, excessive internal heat; 3 literatures involved obesity. The syndromes include Spleen deficiency dampness resistance type; 9 literatures involved hyperlipidemia. The syndromes include Phlegm turbidity blocking type, qi stagnation and blood stasis type; 7 literatures involved hyperuricemia and gout. The syndromes include spleen deficiency phlegm dampness type, blood stasis type and damp heat accumulation type; 92 literatures involved hypertension. The syndromes include phlegm dampness essential, hyperactivity of the liver yang and vigorous liver fire type. Male rats (SD rat,Wistar rat) are involved in the most widely used experimental animals, quail is also applied to hyperuricemia and gout. The modeling method involved are mainly single-factor, dual-factor and hybrid-factor. The main evaluation method of creditial card combining disease and syndrome is to judge and characterize animal model by macroscopic symptoms, signs ( behavior experiments, mental status, livestock manure, tongue images, ect ) and pathological indicators ( glucolipid metabolism, serum biochemistry, liver and kidney function, ect). Conclusions The current modeling method and the main evaluation method of animal models that that combine a disease and a syndrome need to be improved to provide a reliable animal model combining diseases and syndromes for Chinese medicine syndrome differentiation and to establish conditions to study Chinese medicine syndrome differentiation.