Zika virus is an arbovirus of the Flaviviridae family that is transmitted by the bites of Aedes aegypti and Aedes albopictus, by blood and tears, as well as by sexual and vertical mother-to-child transmission. Once a pregnant woman is infected, there is a risk of infection to the fetus. Adults may have some mild clinical symptoms, but fetuses are more vulnerable to central nervous system involvement, which can lead to microcephaly, severe brain defects, and neuroinflammation. Therefore, it is extremely urgent to block the spread and infection of Zika virus. To better understand the mother-to-child transmission route of Zika virus, to study the pathogenic mechanisms, and to discover effective prevention, detection and treatment method , the establishment of reliable animal models is crucial. In this paper, we review the recent progress in mother-to-child transmission of Zika virus in various animal models.