1. BGI-Shenzhen Sanshengyuan Technology Co, Shenzhen 518000, China. 2. Shenzhen Engineering Laboratory for Genomics-Assisted Animal Breeding, Shenzhen 518000. 3. BGI-Agricultural Application Research Institute, Shenzhen 518000. 4. Chongqing Medical and Health School, Chongqing 408000. 5. the Second People’s Hospital of Shenzhen,the First Affiliated Hospital of Shenzhen University, Shenzhen 518028