Research progress of preparation technology and retrofit strategy of antibodies from mouse to whole human monoclonal antibodies
Received:May 07, 2018  
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DOI:10.3969/j. issn. 1005 - 4847. 2018. 04. 020
KeyWord:murine; whole human; monoclonal antibody; glycosylation; single cell sorting technology
施蕾 湛江市慢性肾脏病防控重点实验室,广东医科大学附属医院肾脏疾病研究所,广东湛江
林洁平 湛江市慢性肾脏病防控重点实验室,广东医科大学附属医院肾脏疾病研究所,广东湛江
廖淑珍 湛江市慢性肾脏病防控重点实验室,广东医科大学附属医院肾脏疾病研究所,广东湛江
招春飞 湛江市慢性肾脏病防控重点实验室,广东医科大学附属医院肾脏疾病研究所,广东湛江
刘华锋 湛江市慢性肾脏病防控重点实验室,广东医科大学附属医院肾脏疾病研究所,广东湛江
潘庆军 湛江市慢性肾脏病防控重点实验室,广东医科大学附属医院肾脏疾病研究所,广东湛江
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      Monoclonal antibodies (mAbs) have become one of the fastest?growing areas in the bio?pharmaceutical industry because of their unique advantages such as high specificity, high potency, and low drug resistance, and they have been successfully used in the treatment of various cancers, autoimmune diseases and other diseases. From the initial development of murine monoclonal antibodies to the current whole human monoclonal antibodies, new preparation techniques, such as single cell sorting and sequencing techniques, have been emerging. Meanwhile, it will help to further improve its stability and affinity by changing the glycosylation level of whole human monoclonal antibody and optimizing the affinity maturation technology of monoclonal antibodies. At present, the efficacy and safety of whole human monoclonal antibodies are still concerned by the industry, and they also face many challenges, such as how to balance them while reducing their immunogenicity, and further improve their affinity, are still promising new technologies or strategies.
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