Purine receptors are divided into P1 and P2 receptors. P2 receptors are divided into the ligand gated ion channel receptor (P2X receptor) and G protein coupled receptor (P2Y receptor). The P2Y₆ receptor is a member of the P2Y family, P2Y₆ receptors are involved in cardiovascular diseases, endocrine diseases and neuropathy diseases, etc. With clopidogrel (P2Y₁₂ receptor antagonist) and other purine receptor blocker approved by the FDA for clinical application, and showed good efficacy,study on biological effect of P2Y₆ receptor also becomes one of the hot researches to new drug target for the P2Y receptor. Based on the development of molecular biological techniques, the research on biological effect of P2Y6 receptor achieved significant advances.