Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Currently, the combination of surgical resection and chemotherapy is the main method of treatment for OS in the clinic. Although, the survival rate has been greatly improved in OS patients with localized disease, the 5-year survival rate has remained <20%. It is very important to understand the cause of disease, to develop novel drugs or therapeutics, and to learn the disease through animal models. This review will introduce the progress of animal models of osteosarcoma over the last years.