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| Establishment of a Rat Model of Ulcerative Colitis by Immunological Sensitization Combined with Local Acetic Acid Irritation |
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| DOI： |
| KeyWord:Immunological sensitization;Local irritation;acetic acid;Ulcerative colitis;Model;establishment;Rat |
| WU Yu-Hong,LI Hai-long,DUAN Yong-qiang,WU Jian-jun,WANG Hong-wei,WEI Yan-ming |
WU Yu-Hong~(1,2)
,LI Hai-long~2,DUAN Yong-qiang~2,WU Jian-jun~2,WANG Hong-wei~(3)
,WEI Yan-ming~1(1.College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730070,China,2.School of Basic Medical Sciences,Gansu College of Traditional Chinese Medcine,Lanzhou 730000,3.Department of Clinical Laboratories,Affiliated Hospital of Gansu College of Traditional Chinese Medcine,Lanzhou 730020)
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| Abstract: |
| Objective To establish a rat model of ulcerative colitis by immunological sensitization combined with local acetic acid irritation.Methods Thirty healthy 2-3-month-old Wistar rats were randomly divided into 3 groups:normal control group,model group and SASP-treated model group(n = 10 rats per group).The ulcerative colitis in the model group and positive group was developed by immunological sensitization with rabbit colon mucosal proteins and local irritation with 5% acetic acid.The rats of the model and pos... |
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