Establishment and CT Diagnosis of Orthotopic Rat Model of Bladder Cancer
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KeyWord:MNU;N-methyl-nitrosourea(MNU);Orthotopic bladder cancer;CT diagnosis;Rat
TANG Xiao-ying,PAN Chun-wu,SUN Jun,HUANG Wei,WANG Hua-feng,SHEN Zhou-jan
TANG Xiao-ying,PAN Chun-wu,SUN Jun,HUANG Wei,WANG Hua-feng,SHEN Zhou-jun(Rui Jin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
Corresponding author: SHEN Zhou-jun
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      Objective To establish an orthotopic rat model of bladder cancer induced by N-methyl-nitrosourea(MNU) and to evaluate the diagnostic value of CT(computed tomography) scanning in this experimental model.Methods 50 SD rats were randomly divided into the control group(group A) with 15 rats and experimental group(group B) with 35 rats.Each rat of group B was treated with 2 mg MNU per dose every other week,totally 4 doses,by per urethra administration.Meanwhile,each rat of group A was treated with normal saline....
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