Establishment and application of osteoporosis animal models
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School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China

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    Abstract:

    With the increasing age of the population, and a large amount of bone calcium loss, osteoporosis has become a major public health problem. Osteoporosis is a “silent disease”, with a high incidence, high disability, and high death rates, which seriously affect quality of life. There are many animal models of osteoporosis, but there is a lack of relevant TCM disease and syndrome factors. Therefore, it can be combined with models that are highly consistent with clinical practice to make it closer to clinical research. In this article, we systematically review the advantages and disadvantages of various method of osteoporosis modeling, the advantages and disadvantages of animal species selection, the time of modeling, the drugs selection, and the application of assessment indicators to provide a reference for the standardization and improvement of animal model research.

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History
  • Received:February 15,2023
  • Online: October 17,2023
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