活体脑部神经递质检测技术的研究进展
作者:
作者单位:

国家烟草质量监督检验中心

基金项目:

中国烟草总公司科技重大专项;中国烟草总公司重点研发项目


Research Progress of Neurotransmitter Detection Technology in Living Brain
Author:
Affiliation:

National tobacco quality supervision & inspection center

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    摘要:

    神经递质作为一种内源性化学物质,在维持人正常生命活动等方面发挥着至关重要的作用。神经递质水平异常会导致人身体、精神以及一些神经退行性疾病的发生。然而,神经递质超低的浓度、复杂的化学性质以及释放模式,使体内其准确检测面临巨大挑战。为了精确监测大脑神经递质,准确了解神经递质释放动力学,对近五年来常用的几种活体检测神经递质的方法及其研究进展进行了综述。详细介绍了微透析法、电化学传感器以及荧光传感器的基本原理及其适用性。

    Abstract:

    As an endogenous chemical substance, neurotransmitter plays a vital role in maintaining normal life activities of people. Abnormal levels of neurotransmitters can lead to physical, mental and some neurodegenerative diseases. However, the ultra-low concentration, complex chemical properties and release modes of neurotransmitters make their accurate detection in vivo a great challenge.In order to accurately monitor neurotransmitters in the brain and accurately understand the release kinetics of neurotransmitters, several commonly used methods for detecting neurotransmitters in vivo in the past five years and their research progress were reviewed.The basic principle and applicability of microdialysis, electrochemical sensor and fluorescence sensor are introduced in detail.

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  • 收稿日期:2023-05-24
  • 最后修改日期:2023-07-01
  • 录用日期:2023-09-27
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