Objective To study the effect on ovarian tumor migration invasion after inhibition the expression of IGFBP2, IGFBP3.Methods siRAN interference IGFBP2, IGFBP3 expression in ovarian cancer cell lines SKOV3, SKOV3 proliferation detected by CCK-8 kits,SKOV3 apoptosis detected by flow cytometry,SKOV3 migration and invasion detected by transwell experiment and scratched cell healing detection; CCK-8 method detected survival after treated different concentrations of cisplatin (5, 10, 15, 20 ug/mL). Results The proliferation ability of SKOV3 dropped and apoptosis increased after treated siRAN IGFBP2, IGFBP3 compared with the control group, migration and invasion function decline, resistance level to improve greatly. Conclusions The expression of IGFBP2, IGFBP3 in ovarian cancer affected migration and invasion.