慢性应激实验动物模型的应用与展望
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1. 河北北方学院微循环研究所&2.基础医学院,张家口 075000;3.2. 河北省急危重症发病机制及干预重点实验室,石家庄&4.张家口 050017&5.075000;6.3. 河北医科大学基础医学院,石家庄 050017

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河北省硕士研究生创新能力培养资助项目


Application and prospect in experimental animal model of chronic stress
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Affiliation:

1. Institute of Microcirculation &2.Basic Medical College, Hebei North University, Zhangjiakou 075000, China;3.2. Hebei Key Laboratory of Acute and Severe Disease Pathogenesis and Intervention, Shijiazhuang &4.Zhangjiakou, 050017 &5.075000;6.3. Basic Medical College, Hebei Medical University, Shijiazhuang 050017

Fund Project:

Hebei Province graduate student innovation ability training funding project

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    摘要:

    慢性应激对人类心身疾病的作用与机制是应激研究领域的热点。建立动物模型模拟人类慢性应激状态,在应激反应原理、相关疾病发生机制、临床治疗和药物研发方面有重要意义。本文综述了国内外常用的慢性应激动物模型,总结了应激原分类、动物选择、模型建造、病理表现和评价指标,讨论了各种模型的优缺点及应用进展,期望为研究慢性应激反应的模型选择提供参考。

    Abstract:

    The effect and mechanism of chronic stress on psychosomatic diseases is a hot topic in the field of stress research. The establishment of animal models to simulate human chronic stress state is of great significance in the principle of stress response, the pathogenesis of related diseases, clinical treatment and drug development. In this paper, the commonly used animal models of chronic stress at home and abroad were reviewed, the classification of stressors, animal selection, model construction, pathological manifestations and evaluation indexes were summarized, and the advantages and disadvantages and application progress of various models were discussed, hoping to provide references for the study of model selection of chronic stress response.

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  • 收稿日期:2023-10-07
  • 最后修改日期:2024-03-03
  • 录用日期:2024-03-20
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