刹车片颗粒及其主要成分硫化锑呼吸暴露对小鼠健康危害研究
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中国医学科学院医学实验动物研究所

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]国家重点研发计划项目(2022YFF0710803、2022YFF0710800、2021YFF0703400)、国家自然科学基金面上项目(82070103)、中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-036,2018-I2M-1-001)。


Experimental study on the health hazards of brake pad particles and their main component antimony sulfide respiratory exposure in mice
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Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences

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National Key R&D Program Projects (2022YFF0710803, 2022YFF0710800, 2021YFF0703400), National Natural Science Foundation Project (82070103), CAMS Innovation Fund for Medical Science Project (2021-I2M-1-0362018-I2M-1-001).

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    摘要:

    目的 研究刹车制动来源颗粒物对机体的潜在危害。方法 研磨刹车片颗粒、硫化锑颗粒,小鼠通过气管灌注暴露1个月后,观察肺、心、肝等内脏器官病理改变,同时流式细胞术分析外周血巨噬细胞和自然调节T淋巴细胞(regulatory T cell, Treg)的变化。结果 刹车片颗粒及硫化锑颗粒暴露小鼠肺泡壁外源物质沉积,血管周围出现明显的炎症细胞浸润并随着暴露浓度的增加而加重,同时可出现心脏血管炎症和微血栓以及肝细胞肿胀等病理改变;Treg细胞减少,硫化锑组和低剂量刹车片组巨噬细胞增加,同时M2型巨噬细胞比例下调。结论 刹车片颗粒及其成分硫化锑颗粒暴露对小鼠肺、心、肝等脏器具有不同程度的毒性作用,并对免疫系统造成了影响,提示刹车来源的空气污染的潜在健康危害。

    Abstract:

    Objective To study the potential harmful effects of brake source particles. Methods Grind the brake pad particles or antimony sulfide particles. Subsequently, the mice were exposed through tracheal perfusion for 1 month to observe pathological changes in in the lungs, heart, and liver, and flow cytometry was used to analyze the changes in peripheral blood macrophages and regulatory T cells (Treg). Results After exposure, there was deposition of foreign substances in the alveolar wall of mice, with obvious infiltration of inflammatory cells around blood vessels, which worsened with increasing exposure concentration. In addition, pathological changes such as vascular inflammation and microthrombosis in the heart, and hepatocyte swelling in the liver were observed. Treg cells in peripheral blood decreased and macrophages increased in the antimony sulfide group and low-dose brake pad particles group, while the proportion of M2-type macrophages decreased. Conclusions Exposure to brake pad particles and their component antimony sulfide particles has varying degrees of toxic effects on the lung, heart, and liver of mice, and has a impact on the immune system, indicating the potential health hazards of brake-derived air pollution.

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  • 收稿日期:2023-09-08
  • 最后修改日期:2023-11-03
  • 录用日期:2024-02-26
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