Leukaemia is a critical disease with a high incidence in clinic at present, with an extremely high fatality rate. Among them, immune escape from leukaemia stemcells(LSC) is the main factor for recurrence and progression after leukaemia-induced remission. The clinical diagnosis and treatment of TCM has distinct advantages of syndrome differentiation and treatment. Based on the purpose of diagnosis and treatment, the treatment of leukaemia by TCM emphasises the "harmony of yin and yang" to estore human function, which is conducive to improving the body's autoimmunity and conforms to the mechanism of intervention for tumour cell immunity escape. This article discusses the echanism and research progress of TCM intervention in Lsc immune escape from literature research and TCM theory.