The liver is the most common organ for tumor spread, and expression of miRNA is crucial for liver metastasis. In this study, research progress of related miRNAs in regulating liver metastases from malignant tumors in the digestive system was collated and analyzed. By searching related literature, this article provides an introduction to the role of miRNAs in liver metastasis of colorectal, gastric, pancreatic, and gallbladder cancers, which helps with the diagnosis, treatment, and research of tumor liver metastasis.