Abstract:AIM: To establish a the esophageal varices model of New Zealand white rabbits, reliable small animal model for further clinical studies. METHODS: Twenty rabbits were used in the study. Esophageal varices were estalished by complete ligation of the left portal vein. RESULTS: All the rabbits who survived had developed esophageal varices that were demonstrated by endoscopy. CONCLUSION: A rabbit model of Esophageal Varices be established sueeessfully with this method.