Effect of Paraquat on neurobehavioral development and learning ability in mice
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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    Abstract:

    【Abstract】Object To observe the effect of Paraquat on neurobehavioral development and learning ability in C57BL/6J mice.Methods Eighty neonatal C57BL/6J mice were randomly divided into five groups, i.e.. Saline(the control group),1.25mg/kg/d, 2.5mg/kg/d,5mg/kg/d,10mg/kg/d Paraquat groups. The chemical was given by lavage in the volume 0.1mL/10g body weight for 30 days. Neural behaviors were examined by using the Morris water maze test and passive avoidance task after administration.The brain organ weight and histological changes were examined. Ultrastructural changes of the substantia nigra were observed under the transmission electron microscope.Results No significant change of body weight was observed among groups and no significant difference was observed in the time of the Morris water maze test (P>0.05).The results of passive avoidance task in high dose group was longer than that in the control group, there was a significant difference(P﹤0.05) .Brain Lesions were observed both in the transmission electron microscope and tissue sections.Conclusion C57BL/6J mice exposed to paraquat during the developmental period could yield the alterations of behavior and pathological and biochemical changes.

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History
  • Received:November 02,2012
  • Revised:November 15,2012
  • Adopted:December 08,2012
  • Online: April 18,2013
  • Published: