Objective To study the method of insulin resistance model and effect of 1,1-Diphenylethylene on the regulation of blood sugar. Methods 1. Fat emulsion was given the Wistar rats and made animal models of insulin resistance. 2.Insulin was given HepG2 cells and made HepG2/IR cells model of insulin resistance. 3. Three were given a model in rats and HepG2/IR cells 1,1-Diphenylethylene observed regulation effect of 1,1-Diphenylethylene on blood sugar. Results Level of blood glucose, TG, the TC and LDL HDL of rats after giving the fat emulsion, were increased by 72.87% and 16.21%，139.93%，56.93%，18.32%,compared with the modeling before, the difference was significant (P<0.01); after giving 1,1-Diphenylethylene,levels of blood glucose and lipid significantly reduced than before administration (P<0.05 to 0.01); glucose consumption of HepG2/IR group increased significantly than that of control group(HepG2). Conclusions The insulin resistance models were copied by given to Wistar rats fat emulsion or given to HepG2 cells insulin; 1,1-Diphenylethylene has effects of reduce level of blood glucose and lipids of animal models, increase glucose consumption of HepG2/IR cells