Objective We focused on solving a problem in the infection course of cecum ligation and puncture (CLP) septic model animals, i. e. , the random occlusion of ligation and puncture sites due to bowel edema. To establish a septic animal model with a sustainable infection, we combined cecal ligation puncture and bacterial carrier implantation with a compound infection stent. Methods Fifty-four male SD rats were randomly divided into three groups: Sham ( n= 18), CLP (n= 18), and multiple infect model (MIM,n= 18) groups. In each group, 10 rats were investigated for their survival status, intra-abdominal infection, and survival rate. Another 8 rats were selected for studying related indicators of sepsis multiple organ dysfunction syndrome (MODS) injury. The detected indicators included LPS, IL-6, cTn-I, ALT, AST, TBil, Lac, and Cr abdominal aortic blood contents; MDA and ATP liver tissue contents, and HE staining of pathological changes in heart, liver, lung, and kidney tissue. Results 96 h after molding operation, there were no deaths in the Sham group, and survival rates in the CLP and MIM groups were 70% and 0%, respectively. The degrees of injury in the heart, liver, lungs, and kidneys in the MIM group were greater than those in the CLP model group. Compared with the Sham and CLP groups, the MIM group had the highest contents of LPS, IL-6, cTn-I, ALT, AST, TBil, Cr, Lac, and MDA and the lowest of ATP, all of which were significantly different (P< 0. 05). The coefficients of variation for LPS, IL-6, TBil, and MDA in the MIM group were significantly decreased in relation to those of the CLP group. Conclusions The MIM group’s intestinal contents leaked continuously to cause persistent infection, which result ed in much lower variability in key infection and inflammation indicators (LPS, IL-6, MDA, etc. ) and a more consistent course of disease than in the CLP group. Thus, the structural validity of the MIM model was better. Compared with the CLP group, the MIM group had more severe postoperative infections, deeper organ damage, higher mortality, more consistent within-group death times, and thus had greater face validity. Therefore, the MIM model best fits with the clinical profile of septic-MODS, which is caused by an over-reaction to severe infection.