Abstract:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, which can lead to joint deformity and dysfunction. Animal models of RA simulate the pathological and physiological processes of its occurrence and development, and are widely used in RA studies. Multimodal ultrasound technology allows qualitative and quantitative diagnosis of RA, monitors changes in conditions, evaluates drug efficacy, and guides local administration and targeted therapy, providing an accurate evaluation method for research of RA animals. This article reviews the application of multimodal ultrasound in the diagnosis and treatment of RA animal models.