Applicability of zebrafish larvae in the research of acute kidney injury
Received:January 14, 2022  
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DOI:10. 3969 / j.issn.1005-4847. 2022. 06. 016
KeyWord:zebrafish; acute kidney injury; animal model; larvae
王雪 齐鲁工业大学山东省科学院,山东省科学院生物研究所,济南
夏青 齐鲁工业大学山东省科学院,山东省科学院生物研究所,济南
王荣春 齐鲁工业大学山东省科学院,山东省科学院生物研究所,济南
王西新 齐鲁工业大学山东省科学院,山东省科学院生物研究所,济南
张云 齐鲁工业大学山东省科学院,山东省科学院生物研究所,济南
刘可春 齐鲁工业大学山东省科学院,山东省科学院生物研究所,济南
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      As an emerging vertebrate animal model, zebrafish have been widely used in human disease research. Although simple in form, the larval pronephros is similar to the mammal kidney in terms of histological structure, gene expression, and functional complexity. Furthermore, the response of zebrafish larvae to kidney damage is similar to that of mammals. Because of their unique features and other advantages, zebrafish larvae present a useful model for research into kidney development and disease. This review discusses the applicability of zebrafish larvae in research into acute kidney injury based on the biological characteristics of the pronephros, the pathogenic mechanisms involved, and the advantages for kidney injury research.
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