Classification and research progress on animal models of Alzheimer’s disease prepared by D-galactose
Received:September 02, 2021  
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DOI:10. 3969 / j.issn.1005-4847. 2022. 06. 015
KeyWord:Alzheimer’s disease (AD); D-galactose (D-gal); animal model; classification; review
魏玉婷 甘肃中医药大学针灸推拿学院,兰州
朱田田 甘肃中医药大学针灸推拿学院,兰州
苏明莉 甘肃中医药大学针灸推拿学院,兰州
贾静 甘肃中医药大学针灸推拿学院,兰州
严兴科 甘肃中医药大学针灸推拿学院,兰州
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      As a common neurodegenerative disease, Alzheimer’s disease (AD) seriously affects the physical and mental health, and the quality of life, of patients. The preparation of AD animal models is therefore of significance, especially models that can effectively replicate abnormal behavioral, biochemical, and pathological changes. In this review, the method of preparing AD animal models based on D-galactose alone, and D-galactose combined with an amyloid beta protein (Aβ) oligomer, AlCl3 , and NaNO2 were summarized. The mechanism of drug-induced AD, the presentation of impaired learning memory, and pathological changes such as oxidative stress, inflammatory reactions, neuron damage, and Aβ and Tau aggregation are evaluated and discussed to provide a reference for future studies involving AD animal models.
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