Nicotine addiction models and evaluation of animal behavior
Received:February 22, 2022  
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DOI:10. 3969 / j.issn.1005-4847. 2022. 06. 013
KeyWord:nicotine dependence; animal addiction models; animal behavior; rodents; evaluation method
李凯欣 1. 国家烟草质量监督检验中心,烟草生物学效应重点实验室,转化神经生物学联合实验室,郑州 ;2. 中国科学技术大学,合肥
陈欢 国家烟草质量监督检验中心,烟草生物学效应重点实验室,转化神经生物学联合实验室,郑州
刘方邻 2. 中国科学技术大学,合肥 ;3. 中国科学院合肥物质科学研究院,合肥
刘勇 中国科学院合肥物质科学研究院,合肥
侯宏卫 国家烟草质量监督检验中心,烟草生物学效应重点实验室,转化神经生物学联合实验室,郑州
胡清源 1. 国家烟草质量监督检验中心,烟草生物学效应重点实验室,转化神经生物学联合实验室,郑州 ;2. 中国科学技术大学,合肥 ;3. 中国科学院合肥物质科学研究院,合肥
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      The large number of smokers has had a broad effect on society. Nicotine is one of the most widely concerning components of cigarette smoke. Long-term intake of nicotine can lead to nicotine dependence that affects higher brain functions, which may involve anxiety, learning and memory impairments, and abnormal decision-making. To facilitate analyzing the molecular mechanisms of nicotine dependence, it is common to establish rodent nicotinoid dependence models to better understand the physiological changes. This review summarizes and evaluates studies of the behavior in nicotine-dependent animal models to provide a reliable reference for researchers to establish rodent nicotine- dependent models for evaluation.
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