Abstract:With the rapid development of the manned spaceflight industry in China, research into space medicine is also constantly progressing. The space environment can lead to health problems such as space motion sickness, cardiovascular dysfunction, sleep disturbance, decompression sickness, and infectious diseases in astronauts on-orbit. Studies on the pharmacokinetics of drugs in the body in the space environment are urgently needed to provide a basis for effective clinical drug use in the space environment. This article focuses on the processes of drug absorption, distribution, metabolism, and excretion, and summarizes the pharmacokinetic changes and main mechanisms of action of drugs in the real on-orbit environment and during simulated weightlessness on the ground. Our findings provide a reference for the safe and rational use of drugs during spaceflight.