Research progress on the effect of the space environment on pharmacokinetics
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1.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. 2. Provincial Key Laboratory of Pharmaceutics in Guizhou Province, Engineering Research Center for Development and Application of Ethnic Medicine and Traditional Chinese Medicine, Ministry of Education, School of Pharmaceutical Sciences, Guizhou Medical University, Guiyang 550004

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    Abstract:

    With the rapid development of the manned spaceflight industry in China, research into space medicine is also constantly progressing. The space environment can lead to health problems such as space motion sickness, cardiovascular dysfunction, sleep disturbance, decompression sickness, and infectious diseases in astronauts on-orbit. Studies on the pharmacokinetics of drugs in the body in the space environment are urgently needed to provide a basis for effective clinical drug use in the space environment. This article focuses on the processes of drug absorption, distribution, metabolism, and excretion, and summarizes the pharmacokinetic changes and main mechanisms of action of drugs in the real on-orbit environment and during simulated weightlessness on the ground. Our findings provide a reference for the safe and rational use of drugs during spaceflight.

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History
  • Received:April 08,2022
  • Revised:
  • Adopted:
  • Online: November 11,2022
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