1. School of Pharmacy, Nanjing University of Chinese Medicine, Jiangsu Province Key Laboratory of Pharmacology and Safety Evaluation of Chinese Materia Medicine, Nanjing 210023, China. 2. Hospital of Nanjing University of Chinese Medicine, Nanjing 210029. 3. Nanjing University of Chinese Medicine School of Medicine and Holistic Integrateive Medicine, Nanjing 210023