Tumor metastasis is a complicated process. The concept of the pre-metastatic niche (PMN) reveals the essential factors of tumor metastasis. Experimental animal models have made significant contributions to simulating the process of human diseases, developing new drugs and therapies and clinical trials. In particular, they have been widely used in the study of tumor behavior. The pulmonary metastasis tumor models have the advantages of high reproducibility, high success rates and promising experimental result . Based on the concept of PMN, this article summarizes the method and evaluation indicators of pulmonary metastasis animal models.