Abstract:Parkinson’ s disease ( PD) is a regressive disease of the central nervous system. The movement symptoms of PD mainly includes resting tremor, muscle rigidity, bradykinesia, and postural instability. Because of the lack of research on the human brain and the absence of equivalent spontaneous diseases in animals, the development of rational scientific animal models will provide essential research tools in basic and clinical research into PD. Such models may help us to reveal the pathogenesis of PD, and to develop new treatment strategies and drugs.