Alzheimer’ s disease (AD) is an age-related progressive neurodegenerative disease of the brain. The main clinical feature is cognitive dysfunction. As the global population ages, AD has become a major focus of domestic and international research. Appropriate animal models are of great significance for experimental research on disease mechanisms and drug screening for AD. The AD animal models include natural aging and transgenic models, as well as physically and chemically induced AD models. In this article, we compare and summarize the commonly used animal models in AD research and provide a reference for the selection of appropriate animal models in future studies of AD.