Research progress and evaluation of animal models of hepatorenal fibrosis
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1. Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China. 2. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028

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    Abstract:

    Fibrosis of the liver and kidneys is a pathological process in which extracellular matrix ( ECM) is overdeposited and parenchyma cells are reduced by continuous damage to liver and kidney cells. Liver and kidney fibrosis is an inevitable process of chronic liver and kidney diseases. Except for organ transplantation, the early stage of fibrosis is now considered the key part of treatment for chronic disease. There are currently many rodent models of liver or kidney fibrosis, but only a few models with combined liver and renal fibrosis are available for research and drug screening. This paper summarizes the modeling method and mechanisms of common liver and kidney fibrosis, and composite models. We also compare the merits and demerits of different method to provide a reference for the future establishment and improvement of more clinically relevant compound animal models of liver and kidney fibrosis.

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History
  • Received:May 10,2019
  • Revised:
  • Adopted:
  • Online: February 05,2021
  • Published: