Observation of evaluation points for blood glucose intervention in a mouse model of type 2 diabetes mellitus
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Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Basic Medical College, Lanzhou University, Lanzhou 730000, China

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    Abstract:

    Objective To observe changes of blood glucose in mice with type 2 diabetes mellitus (T2DM), and to explore the feasibility of using 2-hour postprandial blood glucose as an evaluation point of blood glucose intervention. Methods T2DM mice induced by a high-fat diet and streptozotocin ( STZ) were the experimental group and normal C57BL/ 6 mice were used as the control group. Continuous fasting blood glucose and continuous random blood glucose were measured in the two groups, and the blood glucose levels in the mice were analyzed to evaluate the use of 2-hour postprandial blood glucose as an evaluation point of blood glucose intervention in T2DM mice. The stability of the 2-hour postprandial blood glucose evaluation point was verified by the long-term observation of 2-hour postprandial blood glucose fluctuation in diabetic mice. Results The continuous fasting blood glucose of T2DM mice was significantly reduced after fasting for more than 4 hours. In contrast, blood glucose changes in T2DM mice at 2- 3 hours after eating a meal were relatively stable, which might reflect the stability of the model over a long period. For 7 weeks, the 2-hour postprandial blood glucose level of T2DM mice showed it was stable at 2 hours after meals. Conclusions The 2-hour postprandial blood glucose level reflects the stable blood glucose change in T2DM mice, which might have value for the evaluation of blood glucose intervention experiments.

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History
  • Received:August 31,2019
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  • Online: April 29,2020
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