Abstract:Objective The aim of this study was to establish a basis for the identification of porcine immunoglobulin genes in order to facilitate research on swine disease resistance. Further improvements of immunoglobulin gene annotation will facilitate the development of the pig industry and will promote the wider application of pigs as a major biomedical model. Methods Porcine immunoglobulin genes were predicted and classified by comparison with human immunoglobulin genes using R, DNAstar, WebLogo, and Blast+. Results A total of 43 IGH, 27 IGK, and 25 IGL genes were identified in pigs, which could be divided into 7, 6, and 9 gene families, respectively. Conclusions We found 43 immunoglobulin heavy chain genes in pig. Some of them may be pseudogene. Meanwhile, the ratio of light chain genes (IGK ∶ IGL) is approximately 1 ∶ 1. It may be related to the immunological characteristics of pig, which need related experimental data to do its research.