Identification and annotation of the porcine immunoglobulin genes
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1.Provincial Key Laboratory for Farm Animal Genetic Resource Exploration and Innovation, Sichuan Agricultural University, Sichuan 611130, China. 2. Chongqing Academy of Animal Sciences, Chongqing 402460. 3. Key Laboratory of Pig Industry Science of Agriculture Ministry, Chongqing 402460. 4. Chongqing Key Laboratory of Pig Industry Science, Chongqing 402460. 5. Technical Engineering Center for the Development and Utilization of Medical Animal Resources, Chongqing 402460

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    Abstract:

    Objective The aim of this study was to establish a basis for the identification of porcine immunoglobulin genes in order to facilitate research on swine disease resistance. Further improvements of immunoglobulin gene annotation will facilitate the development of the pig industry and will promote the wider application of pigs as a major biomedical model. Methods Porcine immunoglobulin genes were predicted and classified by comparison with human immunoglobulin genes using R, DNAstar, WebLogo, and Blast+. Results A total of 43 IGH, 27 IGK, and 25 IGL genes were identified in pigs, which could be divided into 7, 6, and 9 gene families, respectively. Conclusions We found 43 immunoglobulin heavy chain genes in pig. Some of them may be pseudogene. Meanwhile, the ratio of light chain genes (IGK ∶ IGL) is approximately 1 ∶ 1. It may be related to the immunological characteristics of pig, which need related experimental data to do its research.

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History
  • Received:July 31,2019
  • Revised:
  • Adopted:
  • Online: April 29,2020
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