Objective To dynamically observe the temporal differences of anxiety and depression-like behavior in rats with chronic inflammatory pain induced by complete Freund’ s adjuvant (CFA). Methods All rats were randomly divided into control and model groups. The model group rats was injected with CFA into the hind paws to establish the chronic inflammatory pain model. We dynamically observed the changes of paw withdrawal thresholds before modeling and at 1, 3, 7, 18, and 26 days after modeling. In addition, behavioral changes were observed in an open field test at 28 days, in an elevated zero maze test at 29 days, in a novelty-suppressed feeding test at 29 days, and in a marble-burying test at 12, 20, and 31 days, as well as through a sucrose preference test after modeling at 17, 25, and 35 days. Results Compared with the control group, the paw withdrawal threshold of the model group significantly decreased after 1 day (P< 0. 01) and was significantly lower than the control group throughout the experiment (P< 0. 01). Compared with the control group, the distance in the central area, time in the central area, and number of central zone entries of the model group were significantly reduced in the open field (P< 0. 01). Compared with the control group, the distance in open arm, time in open arm, and number of the open arm entries of the model group were significantly reduced in the elevated zero maze (P< 0. 05). The latency of food of the model group was significantly increased ( P< 0. 05), and there was no significant difference in food consumption in the novelty-suppressed feeding (P> 0. 05). In the marble-burying test, the number of buried marbles in the model group increased significantly compared with the control group ( P < 0. 05) 31 days after modeling. There was no significant difference between the control group and the model group at any time point in the sucrose preference test (P> 0. 05). Conclusions Chronic inflammatory pain induced by CFA can lead to a variety of changes in the anxiety-like behavior of animals after 4 weeks, while no changes in the depression-like behaviors of animal was seen before 5 weeks.