Contrast-induced nephropathy is defined as the sudden deterioration in renal function following the exposure to contrast media. The morbidity and mortality of contrast-induced nephropathy are on the rise, which has become a serious threat to public health. The pathogenic mechanisms of contrast-induced nephropathy have not well elucidated yet.Animal experiments are important in the etiology, pathogenesis as well as the prevention and treatment of the contrastinduced nephropathy. Therefore, the successful development of animal models is the first step of our relevant research. In this paper, we will discuss the progress of generating contrast-induced nephropathy animal models.