Drug resistance is a major problem in the prevention and treatment of epilepsy. Animal models ofepilepsy are powerful tools to study the mechanism of epilepsy, screening antiepileptic drugs, and explore the mechanismsof drug actions. The 6 Hz corneal kindling seizure model is an excellent animal model of drug-resistant epilepsy, which isrecommended by the NIH as a screening tool to evaluate new drugs against drug-resistant epilepsy. However, there iscurrently no systematic report of this model. Here, we review the development history, production method, symptoms,pathogenesis, and application status of the model to provide a reference to explore the pathogenesis of drug-resistant epilepsy and screening drugs for the treatment of drug-resistant epilepsy.