Role of calmodulin kinase II in neuropathic pain and its pathway of pain regulation

doi:10. 3969 / j.issn.1005-4847. 2019. 03. 018

Home > Archive>Volume 27, Issue 3, 2019 >387-392. DOI:10. 3969 / j.issn.1005-4847. 2019. 03. 018

Role of calmodulin kinase II in neuropathic pain and its pathway of pain regulation
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                        10. 3969 / j.issn.1005-4847. 2019. 03. 018
                    
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Affiliation:(1. Third Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310053, China.2. Key Laboratory of Acupuncture and Neurology of Zhejiang Province , Hangzhou 310053.3. Institute of Acupuncture and Moxibustion, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053)
Clc Number:Q95-33
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Abstract:

Ca²⁺ / calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/ threonine proteinkinase in a large number of neurons and is widely involved in pain modulation. Neuropathic pain is chronic refractory paincaused by disease or damage to the somatosensory system. CaMKII plays an important role in the occurrence anddevelopment of various types of neuropathic pain such as central, peripheral, diabetic and drug-induced neuropathic pain.This review focuses on the regulation of CaMKII-mediated neuropathic pain and its upstream and downstream pathways to provide a reference for the future study of CaMKII in the field of neuropathic pain.

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Received:December 11,2018
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Online: July 09,2019
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