Establishment and assessment of a rat model of functional dyspepsia with spleen deficiency
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    Abstract:

    Objective To establish animal models of functional dyspepsia with spleen deficiency and to compare the efficacy of different methods. Methods Rat models were established by iodoacetamide(IA)-treatment or combined with swimming.Appearance,body weight,food intake of the rats were observed,and serum motilin,cholecystokinin,lactate,gastrin content and urinary D-xylose excretion rates were detected to confirm whether the model of functional dyspepsia with spleen deficiency was established. Results The IA-treated rats had less food intake and a slower body weight gain.The IA-treated combined with swimming rats presented spleen-hypofunction symptoms,such as emaciation,hair dry and loose stools, their urinary D-xylose excretion rate, serum motilin, gastrin content were decreased, and serum cholecystokinin and lactate contents were increased significantly (P<0.05 for all). Conclusions All the three methods used in this study can result in symptoms of functional dyspepsia with spleen deficiency.However,IA-treatment combined with swimming models appear more close to spleen deficiency-like presentation, and the best model is the IA-treated combined with platform standing.

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History
  • Received:November 21,2016
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  • Online: July 07,2017
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