Effect of electroacupuncture on the rat model of type 2 diabetes mellitus combined with renal hypertension
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    Abstract:

    Objective To observe the therapeutic effect of acupuncture therapy for the rat model of type 2 diabetes mellitus (T2DM) combined with renal hypertension and try to explore its mechanism. Methods We randomly select 10 Wistar rats as the blank group and 40 rats were used to make the model groups, which were divided into simple diabetes group, simple renal hypertension group, the compound group with electroacupuncture and the compound group without electroacupuncture, with 10 rats in each group. After a high fat and sugar diet for 4 weeks, the Wistar rats were given streptozotocin i.p. injection to establish models of type 2 diabetes mellitus. Renal hypertension was developed by the "2K1C" improved method to make unilateral renal artery ligation-induced renal artery stenosis. Then, electroacupuncture treatment was performed on the rats for 2 weeks except the compound group without electroacupuncture. The changes of values of BP, FBG, Cr, BUN, glycated hemoglobin, renin and Ang Ⅱ were recorded and analyzed.Results The values of BP, FBG, Cr, BUN, glycated hemoglobin, renin and Ang Ⅱ in the compound group with electroacupuncture showed a significant reduction compared with the compound group without electroacupuncture after 2 weeks (P<0.01), but there was no obvious changes in the values of Cr and BUN(P>0.05).Conclusions The blood glucose and blood pressure in the rat model of compound group can be reduced to a normal level with continuous electroacupuncture at bilateral acupoints Zusanli, and it can also be kept at a stable level after single electroacupuncture for 2-3 days. The acupuncture therapy is more suitable for early clinical treatment and can be used in basic research with advantages of economic, safe, no side effect and so on.

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History
  • Received:October 09,2016
  • Revised:
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  • Online: December 20,2016
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