Progress in research on the role of microRNA-424 in carcinogenesis and its related mechanism
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    Abstract:

    A member of miR-16 family, miR-424 has been found to be closely related with tumorigenesis, tumor progrssion, prognosis and therapy. This article reviews the expression changes, roles and possible regulating mechanisms of miR-424 in leukemia and various tumors such as breast, cervical, lung, liver and colorectal cancers. Recent studies have demonstrated that the expression of miR-424 is affected by many factors, and miR-424 could be a biomarker of diagnosis, staging and prognosis in cancers,to identify the area of tumor, and be a target of therapy.

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History
  • Received:March 09,2016
  • Revised:
  • Adopted:
  • Online: November 02,2016
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