Laboratory animal is an important support condition in life science and biomedical research. With the rapid development of life science and biomedical industry, laboratory animals, and quantity and variety of animal model resource are rapidly increasing. According to the statistics, there are more than 200 kinds of a total of more than 26000 strains, including 2607 strains of conventional laboratory animals in the world. USA is a big country of laboratory animal resource in the world, with most of the laboratory animal breed resources and preservation organization. In this paper, we analyzed American laboratory animal resources, and provided references for the development of laboratory animal resource in China.