Imaging evaluation of the therapeutic effect of a Chinese medicine, Shangke Jiegu Tablet, on the rat model of bone fracture
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    Abstract:

    Objective To evaluate the therapeutic effect of a Chinese medicine, Shangke Jiegu Tablet, on the rat model of bone fracture. Methods After anesthesia, complete transverse fracture of the middle portion of the radius in the right forelimb was made in rats. The rats were randomly divided into three groups: model group, treatment group and sham operation group as control. Each group included 20 rats, half male and female. The rats in the treatment group were intragastrically administered the drug in a dose of 0.33 g/kg once daily for 4 weeks, while the model and sham operation groups were given normal saline. After the end of drug administration, images of X-ray, CT and MRI were taken to record the healing of the bone fracture. Finally the rats were sacrificed by anesthesia, and the bones were taken for anti-rupture strength test and routine histopathological examination. Results The imaging examinations clearly showed dense callus formation at the fracture site, and the fracture line was blur or disappeared. Calcium deposition was observed in most fracture sites. It was consistent with the results of histopathological observation. The anti-rupture strength of the healed bones was also obviously increased in the treatment group. Conclusions Medical imaging techniques can be used to more objectively evaluate the therapeutic effects of drug therapy for bone fracture. Especially, the 4-dimensional CT imaging can more clearly and directly reveal the healing process of bone fracture, and is worth of popularization and application.

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History
  • Received:September 09,2014
  • Revised:
  • Adopted:
  • Online: March 04,2015
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