Expressions of fractalkine and TLR4 in atherosclerotic plaques in the common carotid artery of apoE-/- mice
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    Abstract:

    Objective To explore the expression and correlation of fractalkine and TLR4 in atherosclerotic plaques in the common carotid artery of apoE-/- mice. Methods Twenty-four ApoE-/- mice were divided into three groups, fed with standard chow diet (SD), high-fat diet (HF) or HF and atorvastatin (HF+A).12 weeks later, the blood lipids were checked. The plaque area and vascular stenosis rate of the common carotid artery were measured. All the data were used to evaluate the severity of atherosclerotic lesions of the animals. Moreover, immunohistochemical staining was used to examine the levels of fractalkine and TLR4 expressions. Results The plaque area and vascular stenosis rate of the common carotid artery in the HF group were larger than those in the SD group (about 5-fold and 3-fold), but only vascular stenosis rate of the HF+A group was significantly reduced, compared with the HF group (35.27±3.84 vs. 27.02±2.69, P<0.05). The expressions of fractalkine and TLR4 were significantly increased in the HF group (3.24±0.96 vs. 10.69±2.11, 1.29±0.57 vs. 9.32±1.02), and decreased in the HF+A group (10.69±2.11 vs. 5.73±1.30, 9.32±1.02 vs. 3.32±0.51)(P<0.05). Conclusions The expressions of fractalkine and TLR4 are changed synchronously in apoE-/- mouse atherosclerotic plaques. These results suggest that fractalkine and TLR4 may have some inherent relationship, which may play an important role in the development of atherosclerosis.

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History
  • Received:September 25,2014
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  • Online: March 04,2015
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