Abstract:Liver diseases post great threats to human public health globally. Lacking of appropriate small animal models largely impeded the translational studies on human liver diseases, especially on viral hepatitis and related cirrhosis, hepatocellular carcinoma, etc. By human hepatocyte transplantation, the liver-humanized mice have significantly contributed to the researches of human liver diseases. This review summarizes the currently widely used and representative humanized mouse models, including uPA, FAH, TK-NOG, AFC8 mice and their applications in studies of human liver diseases.