Objective Using Morris water maze test to evaluate the effects of guanosine and curcumin on cognitive function of APPswe/PS1dE9 double transgenic mice. Methods 3-month old APPswe/PS1dE9 dtg mice were randomly divided into model group, donepezil HCL group, guanosine group, curcumin group, curcumin and guanosine group (n=12), with age-matched Wild C57BL/6J mice of the same genetic background as normal control group. Medication was given once a day for 1 month. Using Morris water maze to test the spatial learning and memory ability of mice. Results Guanosine and curcumin could improve spatial learning and memory disorders of AD mice, particularly in the group of curcumin.Conclusion Guanosine and curcumin improve the cognitive ability of APPswe/PS1dE9 double transgenic mice with early cognitive impairment.