The outbreak of human infections caused by novel avian-origin influenza A (H7N9) in China has brought serious and huge challenge for our health, agriculture, and economy. Although the epidemic situation has been controlled, the succeeding sporadic cases warn us that the epidemic may not have faded away. There are still too many uncertain issues about the H7N9 virus. Based on this situation, this review will focus on the research progress and perspectives for future critical H7N9 influenza virus topics, and serve as a modest spur to induce other researchers to come forward with their valuable contributions.