Application value of combined detection of urine microalbumin, β2-microglobulin, transferrin, glycated hemoglobin and serum lipids in macaque monkey models of diabetes mellitus
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    Abstract:

    ObjectiveTo explore the application value of combined detection of microalbumin, β2-microglobulin, TRF, glycated hemoglobin and serum lipids in diabetic rhesus macaque models. Methods Streptozotocin in a dose of 30 mg/kg of body weight was intravenously injected to five rhesus macaque for consecutive 3 days. The dynamic changes of urine microalbumin, β2-microglobulin, TRF, glycated hemoglobin were measured for 13 months. Resultsβ2-microglobulin and transferrin were significantly higher than those before STZ injection (P<0.05). The metabolism of TC and HDL-C were abnormal 6 months after STZ injection. Abnormal TG and LDL-C metabolism occurred 9 months after STZ injection. Significantly positive correlations were observed between TRF and β2-MG (F=0.2,0.153, P < 0. 05), mALB and TRF (F=0. 213, P< 0. 05), as well as HbAlc and β2-MGTRF ( F=0. 3,0.097, P< 0.05). There was a positive correlation between urine mALB and β2-MG (F=0.2,0.153, P < 0. 05), between TRF and β2-MG (F=0.213, P< 0. 05), and between HbAlc and β2-MG (F=0.3,0.097, P< 0. 05). Single factor linear regression analysis showed that TRF was a correlation factor of mALB and β2-MG ( P < 0. 05). ConclusionsThe results show that the combined detection of urine microalbumin, β2-microglobulin, glycated hemoglobin and serum lipids can be used in rhesus macaque models of diabetes mellitus, and are useful in their early monitoring, diagnosis, therapy and prognosis.

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