Objective To investigate whether exercise-training on a treadmill can induce physiological cardiac hypertrophy in mice,and to determine the difference between the physiological and pathological cardiac hypertrophy.Methods Forty wild-type male C57BL/6 mice were randomly divided into four groups(10 mice in each group): normal control,training group,sham control,and transverse aortic constriction(TAC) surgery group.After treadmill training for 40 days and at 2 weeks after TAC surgery,the heart function and str...