Huntington's disease(HD) is an autosomal dominant genetic disease characterized by dance-like invol-untary movements and progressive cognitive impairment.Excitatory toxicity is recognized as one of the mechanisms of HD pathogenesis.Quinolinic acid(QA) is an excitotoxic drug,which can lead to brain dysfunction by killing the related neu-rons in the brain,and being a further mimic of changes in HD.This article presents the merits and drawbacks of animal HD models induced by QA as well as the current applicati...