Abstract:Objective To assess the XAGE-3 homologous characteristics in primate and rodent species,and to analyze the XAGE-3 biological function in transgenic mice.Methods Based on the databases Homologene and Taxplot,to compare the homologous characteristics in different genomes,to clone XAGE-3 gene from human placenta,to construct the eukaryotic expression vector pCDNA3.1(+ ),to create transgenic mice by microinjection,to identify the genotyping and the expression of transformed gene by genomic PCR and reverse trans...