Impact of Smad3 Gene Knockout Bone Marrow Transplantation on Mice
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KeyWord:Smad3~(-/-);bone marrow;Activated T cells;Transplantation;bone marrow;Mouse
CHEN Jing~(1,2)
,SHEN Hong~(1,ZHAO Yong~2(1.Department of Animal Science , Technology,Beijing University of Agriculture,Beijing 102206,China,2.State key Laboratory of Biomembrane , Membrane Biotechnology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101)
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      Objective To investigate the changes of T cells and disease development in the mice with Smad3 deficiency in the bone marrow cells.Methods Bone marrow cells obtained from Smad3 null(Smad3~(-/-)) mice and wild type(Smad3~(+/+)) mice were injected to(()Co~(60))-irradiated GFP mice,respectively.The general states of the bone marrow recipients were observed.The mice were sacrificed at the sixth week and the histopathological changes in the intestines were examined.The changes of T cells from lymph nodes were de...
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