Objective To generate D-galactose-induced glycation at different levels in rats,to understand the role of advanced glycation end-products(AGEs) in the mechanism of kidney injury,and the action of its drug intervention.Methods The rats were administrated intraperitoneally with D-galactose in a dose of 150 mg/kg,75 mg/kg or 37.5 mg/kg,respectively,for 8 weeks to induce the glycation condition and kidney injury.At the same time,aminoguanidine(150 mg/kg) and vitamin E(150 mg/kg) were administrated with D-galact...